Fig. 4
The Manhattan plot of conjFDR results and shared genetic loci enrichment. A The Manhattan plot of conjFDR results. The x-axis is the position of genetic variant in the genome, and y-axis is the -log10 (P-value) of the corresponding genetic variant; B The enriched traits in the GWAS catalog. a includes the following: ankylosing spondylitis, Crohn’s disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis; b includes the following: myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chronic ischemic heart disease; c includes the following: combined parental attained age, Martingale residuals; d includes the following: agents acting on the renin-angiotensin system; e includes the following: oligoarticular or rheumatoid factor-negative polyarticular; C The cumulative hazard of cardiovascular diseases stratified by rheumatoid arthritis and diastolic blood pressure. Participants were grouped on the basis of their diabolic blood pressure levels (normal [< 90 mmHg] vs. high [≥ 90 mmHg]) and rheumatoid arthritis (no vs. yes): RA( −) DBP( −), RA( +) DBP( −), RA( −) DBP( +) and RA( +) DBP( +). D The cumulative hazards of rheumatoid arthritis stratified by cardiovascular diseases and diastolic blood pressure. Participants were grouped on the basis of their diabolic blood pressure levels (normal [< 90 mmHg] vs. high [≥ 90 mmHg]) and cardiovascular disease (no vs. yes): CVD( −) DBP( −), CVD( +) DBP( −), CVD( −) DBP( +) and CVD( +) DBP( +)