Table 3 Multiple cox regressions on the risk of major outcomes according to latent classes
| Â | Low complexity class | CV risk factors class | Atherosclerotic class | Thromboembolic class | Cardiometabolic class | High complexity class |
|---|---|---|---|---|---|---|
Primary outcome | ||||||
Composite of all cause death and MACE | ||||||
 IR [95%CI] | 3.4 [3.2–3.6] | 2.6 [2.4–2.9] | 8.5 [7.8–9.3] | 5.5 [4.9–6.2] | 6.4 [5.7–7.2] | 6.9 [6.1–7.8] |
 aHR [95%CI] | Ref. | 0.87 [0.76–1.00] | 1.34 [1.13–1.57] | 1.23 [1.03–1.48] | 1.37 [1.13–1.67] | 1.47 [1.24–1.75] |
Secondary outcomes | ||||||
All cause death | ||||||
 IR [95%CI] | 2.6 [2.4–2.8] | 1.8 [1.6–2.0] | 6.5 [5.8–7.2] | 4.1 [3.6–4.7] | 4.6 [4.0–5.3] | 5.6 [4.9–6.4] |
 aHR [95%CI] | Ref. | 0.83 [0.71–0.97] | 1.35 [1.13–1.63] | 1.28 [1.04–1.57] | 1.33 [1.07–1.66] | 1.61 [1.33–1.95] |
CV death | ||||||
 IR [95%CI] | 0.9 [0.8–1.0] | 0.6 [0.5–0.7] | 2.8 [2.4–3.3] | 1.1 [0.9–1.5] | 1.8 [1.4–2.3] | 2.0 [1.6–2.5] |
 aHR [95%CI] | Ref. | 0.81 [0.62–1.06] | 1.37 [1.02–1.85] | 1.19 [0.82–1.71] | 1.32 [0.91–1.89] | 1.50 [1.09–2.09] |
MACE | ||||||
 IR [95%CI] | 1.6 [1.5–1.8] | 1.4 [1.2–1.6] | 5.1 [4.5–5.7] | 2.8 [2.3–3.3] | 3.6 [3.1–4.2] | 3.5 [2.9–4.2] |
 aHR [95%CI] | Ref. | 0.91 [0.75–1.09] | 1.51 [1.20–1.89] | 1.23 [0.96–1.58] | 1.49 [1.14–1.95] | 1.39 [1.09–1.78] |
Thromboembolism | ||||||
 IR [95%CI] | 0.9 [0.8–1.1] | 1.0 [0.9–1.2] | 2.0 [1.7–2.4] | 2.7 [2.3–3.2] | 1.4 [1.0–1.8] | 1.8 [1.4–2.3] |
 aHR [95%CI] | Ref. | 0.98 [0.78–1.24] | 1.46 [1.06–2.02] | 1.26 [0.94–1.68] | 1.34 [0.91–1.96] | 1.35 [0.97–1.88] |
Major bleeding | ||||||
 IR [95%CI] | 0.9 [0.8–1.0] | 1.0 [0.9–1.2] | 1.7 [1.4–2.1] | 1.1 [0.8–1.4] | 1.9 [1.6–2.4] | 2.6 [2.1–3.1] |
 aHR [95%CI] | Ref. | 1.04 [0.82–1.32] | 1.72 [1.24–2.38] | 1.12 [0.77–1.63] | 1.77 [1.24–2.51] | 2.19 [1.61–2.97] |