Table 2 Comparison of LNM predictions in different cohorts using the MMD-DL model
Cohorts | AUC | Accuracy | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|---|---|
Pre-training (n = 488) | 0.91 [0.89, 0.94] | 85 (351/412) [81, 88] | 83 (180/216) [78, 88] | 87 (171/196) [82, 92] | 88 (180/205) [83, 91] | 83 (171/207) [78, 87] |
Training (n = 109) | 0.85 [0.78, 0.92] | 74 (81/109) [65, 82] | 72 (36/50) [57, 83] | 76 (45/59) [63, 86] | 72 (36/50) [57, 83] | 76 (45/59) [63, 86] |
Test (n = 39) | 0.85 [0.73, 0.97] | 80 (31/39) [64, 91] | 63 (12/19) [39, 83] | 95 (19/20) [73, 99] | 92 (12/13) [62, 99] | 73 (19/26) [52, 88] |
Validation (n = 70) | 0.81 [0.73, 0.89] | 80 (56/70) [69, 89] | 69 (22/32) [50, 84] | 89 (34/38) [75, 97] | 85 (22/26) [68, 93] | 77 (34/44) [69, 89] |
 Hospital 1 (n = 23) | 0.78 [0.57, 0.99] | 83 (19/23) [61, 95] | 89 (8/9) [51, 99] | 79 (11/14) [49, 94] | 73 (8/11) [39, 93] | 92 (11/12) [60, 99] |
 Hospital 2 (n = 28) | 0.77 [0.59, 0.95] | 79 (22/28) [54, 94] | 89 (8/9) [51, 99] | 74 (14/19) [51, 99] | 62 (8/13) [32, 85] | 93 (14/15) [66, 100] |
 Hospital 3 (n = 19) | 0.84 [0.67, 1.00] | 79 (15/19) [59, 92] | 60 (6/10) [27, 86] | 100 (9/9) [63, 100] | 100 (6/6) [52, 100] | 70 (9/13) [39, 90] |