Fig. 7
From: Olfactory bulb anomalies in KBG syndrome mouse model and patients
OB hypoplasia in KBG syndrome patients. Coronal multiplanar reformatting three-dimensional high resolution heavy T2-weighted images of the naso-ethmoidal region. A–D Patient #1; MRI at 14 years of age. E–H Normal control anatomy. The olfactory bulb is not clearly visible in KBG syndrome patient as compared to the normal subject (arrowheads). In addition, the olfactory grooves are severely hypoplastic and the straight gyri (dotted arrows in A–D) are dysmorphic with less prominent and organized adjacent sulci with respect to the normal anatomy (arrow in E–H). I Patient #2; MRI at 3 years of age. J Normal control anatomy. No olfactory bulbs are seen in the KBG syndrome patient and consequently there are no olfactory grooves. The olfactory sulci are visible (arrow). Olfactory bulbs (arrowhead) are visible within well-formed olfactory grooves of the control. The olfactory sulci (arrow) can also be seen