Fig. 2

Trial-level surrogacy plot. a Time to culture negative status on LJ. b Time to culture negative status in MGIT. c BA(0–56), daily rate of change in log10(TTP) to day 56. The difference between treatments on the intermediate marker is plotted against the difference in unfavourable outcome with 95 % confidence intervals. Points lying outside the yellow regions indicate that the treatment difference is in the opposite direction on the intermediate marker from the long-term clinical outcome